Treatment of Capecitabine Corneal Side Effects With Autologous Blood-derived Serum Eye Drops
نویسندگان
چکیده
Background/Aim: To describe the clinical progress and management of ocular side effects in a 35-year-old patient with metastatic breast cancer who underwent oral chemotherapy capecitabine lapatinib. Materials Methods: Slit lamp evaluation revealed bilateral perikeratic hyperemia, perilimbal conjunctival edema associated corneal marginal infiltrates epithelial anterior stromal defects both eyes. examination, vivo confocal microscopy anterior-segment optical coherence tomography were highly suggestive for limbal stem cell deficiency. The decision to administer autologous blood- derived serum eye drops was made. Results: Following administration blood-derived drops, infiltrates, significantly regressed eyes after only 10 days. Chemotherapy resumed prescribed simultaneously. Conclusion: Autologous may be an adequate therapeutic choice lesions detected as capecitabine.
منابع مشابه
Autologous serum eye drops for the treatment of persistent corneal epithelial defects.
A series of 10 patients at Armed Forces Institute of Ophthalmology, Rawalpindi, from September 2009 to August 2010 is reported. Follow-up of patients were done till February 2012. Patients with persistent corneal epithelial defects (PED) of minimum 2 weeks duration, in whom conventional therapy had failed, were included in the study. They were prescribed 100% autologous serum eye drops on hourl...
متن کاملusage of autologous serum eye drops
tears have antimicrobial, nourishing, mechanical, and optical properties and contain components such as growth factors, fibronectin and vitamins to support proliferation, migration and differentiation of corneal and conjunctival epithelial cells. lack of these epitheliotrophic factors, as in dry eye, can result in severe ocular surface disorders such as persistent epithelial defects. recently, ...
متن کاملSystemic side effects with eye drops.
These results show clearly that a single course of Seatone was not superior to a fish extract in rheumatoid arthritis. Previous evidence for the effectiveness of Seatone is slender. The anti-inflammatory activity shown by Miller and Ormrod' was obtained by intraperitoneal and not oral administration. Intraperitoneal administration of chemicals may have a spurious anti-inflammatory effect and is...
متن کاملInfliximab eye drops treatment in corneal neovascularization
Corneal neovascularization is a serious condition that may arise secondary to chemical burns, ischemia, infection, trauma, and inflammation and represents a major cause of blindness. This study investigated the efficacy of topical application of infliximab [tumor necrosis factor-a (TNF-a) monoclonal antibody] in the treatment of corneal neovascularization in the rabbit model.
متن کاملLong-term use of autologous serum 50% eye drops for the treatment of dry eye disease.
PURPOSE The aim of this study was to describe the outcomes of 50% autologous serum (AS) eye drops after long-term use in a large cohort of patients with dry eyes. METHODS A retrospective cohort study was conducted on all patients treated with 50% AS eye drops at our institution between June 2008 and January 2013. Records were reviewed for clinical history, systemic risk factors, dry eye etiol...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: in Vivo
سال: 2021
ISSN: ['0258-851X', '1791-7549']
DOI: https://doi.org/10.21873/invivo.12451